Benzenesulfonyl(thio)ureas for the treatment of septic shock...

Details Benzenesulfonyl(thio)ureas for the treatment of septic shock... Benzenesulfonyl(thio)ureas for the treatment of septic shock...

A - Human Necessities

61

K

A61K 31/17 (2006.01) A61K 31/64 (2006.01) A61P 31/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2450002

The present invention relates to the use of substituted benzenesulfonylureas and benzenesulfonylthioureas of the formula (I), in which R1, R2, E, X, Y and Z have the meanings given in the claims, for treating pathological changes in blood pressure associated with the disease patterns of septic shock and generalized inflammatory syndrome, and to their use for producing medicaments for this purpose.

Cette invention se rapporte à l'utilisation de benzène-sulfonyl-urées et benzène-sulfonylthio-urées substituées représentées par la formule (I), où R?1¿, R?2¿, E, X, Y et Z ont les significations données dans les revendications. Ces composés servent à traiter les modifications pathologiques de la pression sanguine associées aux aspects pathologiques du choc septique et du syndrome inflammatoire généralisé, cette invention se rapportant également à l'utilisation de ces composés pour la production de médicaments prévus à cet effet.

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