Benzenesulphonamide derivatives, their preparation and their...

Details Benzenesulphonamide derivatives, their preparation and their... Benzenesulphonamide derivatives, their preparation and their...

C - Chemistry, Metallurgy

07

C

C07C 311/37 (2006.01) C07C 31/18 (2006.01) C07C 303/40 (2006.01)

Patent

CA 2227912

Benzenesulphonamide compounds of general formula (I), wherein R1 is a hydrogen or halogen atom such as chlorine or fluorine, or a straight or branched C1-4 alkyl or C1-4 alkoxy group, each of R2, R3 and R4, which are the same or different, is a hydrogen atom or a straight, branched or cyclic C1-4 alkyl group, and R5 is a hydrogen atom or a C1-2 alkyl, C1-2 fluoroalkyl or C1-2 perfluoroalkyl group, in the form of enantiomers, diastereoisomers or mixtures thereof, including racemic mixtures, as well as pharmaceutically acceptable acid addition salts thereof, are provided for therapeutical use.

Composés de benzènesulfonamide de formule générale (I) dans laquelle: R¿1? représente un atome d'hydrogène ou d'halogène, tel que chlore ou fluor, ou un groupe C¿1-4? alkyle ou C¿1-4? alcoxy, linéaire ou ramifié, R¿2?, R¿3?, et R¿4? représentent, indépendamment les uns des autres, des atomes d'hydrogène ou des groupes C¿1-4? alkyle, linéaire, ramifié ou cyclique, et R¿5? représente un atome d'hydrogène, un groupe C¿1-2? alkyle, C¿1-2? fluoroalkyle, ou C¿1-2? perfluoroalkyle, sous forme d'énantiomères ou de diastéréoisomères, ou de mélanges de ces différentes formes, y compris de mélanges racémiques ainsi que leurs sels d'addition à des acides pharmaceutiquement acceptables. Application en thérapeutique.

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