C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/228, 260/292
C07D 211/34 (2006.01) A61K 31/445 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2038066
ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) in which: R1 and R2 are independently alkyl, alkoxy, trifluoromethyl, nitro or halogen; A is an aliphatic hydrocarbon group having from 2 to 8 carbon atoms whose chain contains at least 2 carbon atoms in a linear chain between the piperidine group and -COOH, said group optionally being unsaturated; and m and n are independently 0, 1, 2 or 3; and pharmaceutically acceptable salts and esters thereof have been found to have valuable anti-histamine properties without the usual side effects of anti-histamines. Methods of preparing the compounds are also provided.
Fukumi Hiroshi
Iizuka Yoshio
Sakamoto Toshiaki
Sugiyama Mitsuo
Yamaguchi Takeshi
Marks & Clerk
Sankyo Company Limited
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