C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/06 (2006.01) A61K 31/4184 (2006.01)
Patent
CA 2581335
The invention relates to benzimidazole acetic acid compounds which function as antagonists of the Chemoattractant Receptor-homologous molecule expressed on T- Helper type 2 cells (CRTH2) receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metabolites to the CRTH2 reeptor and to treat disorders responsive to such inhibition.
L'invention concerne des composés d'acides benzimidazole acétiques qui fonctionnent comme antagonistes de la molécule homologue de récepteur à fonction chimioattractive exprimée sur le récepteur des cellules T auxiliaires type 2 (CRTH2). L'invention concerne également l'utilisation de ces composés pour inhiber la liaison de la prostaglandine D2 et de ses métabolites ou certains métabolites thromboxane au récepteur CRTH2 et pour traiter des troubles sensibles à une telle inhibition.
Bennani Youssef L.
Gleason Elizabeth Ann
Robarge Michael Joseph
Tumey L. Nathan
Athersys Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Wyeth
LandOfFree
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