C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/305.05, 260/
C07D 235/04 (2006.01) C07D 235/06 (2006.01) C07D 235/08 (2006.01) C07D 235/18 (2006.01) C07D 235/30 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01)
Patent
CA 1126280
ABSTRACT OF THE DISCLOSURE Compounds having diuretic and antihypertensive properties are disclosed which have the following structural formulae: Image or Image or pharmaceutically acceptable salts thereof, wherein: X = halogen or trifluoromethyl Y1 and Y2 = independently hydrogen, alkyl, acyl, azyl, substituted aryl or heterocycle, R1 = hydrogen, lower alkyl, aryl, substituted aryl, benzyl, substituted benzyl, aralkyl, heterocycle or substituted heterocycle, n = 0 or an integer from 1-4 R2 = amino, substituted amino, guanidino, substituted guandino, halogen, alkyl, substituted alkyl, aryl, substituted aryl or heterocycle, and R3 = hydrogen, lower alkyl, aryl, substituted aryl, benzyl, substituted benzyl aralkyl, heterocycle, substituted heterocycle or acyl. Methods of preparation are also disclosed.
324146
Mcfadden Arthur
Shetty Bola V.
Borden Ladner Gervais Llp
Purdue Frederick Company (canada) Ltd. (the)
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