C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61K 31/4535 (2006.01) A61P 29/00 (2006.01) C07D 235/26 (2006.01) C07D 263/58 (2006.01) C07D 277/68 (2006.01) C07D 401/12 (2006.01) C07D 417/14 (2006.01) C07D 471/10 (2006.01) C07D 491/10 (2006.01)
Patent
CA 2534212
Leukotriene A4 hydrolase (LTA4H) inhibitors of formula I, compositions containing them, and their use for the inhibition of LTA4H enzyme activity and the treatment, prevention or inhibition of inflammation and/or conditions associated with inflammation, wherein X is selected from the group consisting of NR5, O, and S, with R5 being one of the H and CH3; Y is selected from the group consisting of CH2 and O; R4 is selected from the group consisting of H, OCH3, Cl, F, Br, I, OH, NH2, CN, CF3.
La présente invention concerne des inhibiteurs de leucotriène A4 hydrolase (LTA4H) représentés par la formule I, des compositions contenant ces inhibiteurs et l'utilisation de celle-ci en vue d'inhiber l'activité de l'enzyme LTA4H et, le traitement, la prévention ou l'inhibition d'inflammation et/ou d'états associés à l'inflammation. Dans cette formule X est sélectionné dans le groupe constitué de CH2 et O; R4 est sélectionné dans le groupe constitué de H, OCH3, Cl, F, Br, I, OH, NH2, CN, CF3.
Axe Frank U.
Bembenek Scott D.
Butler Christopher R.
Edwards James P.
Fourie Anne M.
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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