Benzimidazole carboxamides as raf kinase inhibitors

Details Benzimidazole carboxamides as raf kinase inhibitors Benzimidazole carboxamides as raf kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2531856

The present invention relates to benzimidazole carboxamides of formula (I), the use of the compounds of formula (I) as inhibitors of as inhibitors of one or more kinases, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. Accordingly, the compound of Formula (I) or a pharmaceutically acceptable salt thereof is administered for the treatment of diseases mediated by one or more kinase phathways, preferably by the raf kinase pathway, especially cancers.

L'invention concerne des benzimidazole carboxamides de formule (I), l'utilisation desdits composés de formule (I) en tant qu'inhibiteurs d'une ou plusieurs kinases, l'utilisation des composés de formule (I) pour la fabrication d'une composition pharmaceutique et un procédé de traitement, comprenant l'administration de ladite composition pharmaceutique à un patient. Selon l'invention, le composé de formule (I) ou un de ses sels pharmaceutiquement acceptables est administré pour traiter des maladies médiées par une ou plusieurs voies de kinases, de préférence par la voie de la kinase raf, en particulier des cancers.

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