Benzimidazole compound and pharmaceutical use thereof

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/04 (2006.01) A61K 31/454 (2006.01) A61P 25/00 (2006.01) A61P 25/20 (2006.01) A61P 25/30 (2006.01) A61P 25/32 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2679530

Disclosed is an ORL-1 receptor agonist having more excellent metabolic stability and stronger and higher selectivity than conventional compounds. The ORL-1 receptor agonist is therefore improved in bioavailability. Specifically disclosed is a compound represented by the following general formula (I). (In the formula, the symbols are as defined in the description.)

L'invention porte sur un agoniste des récepteurs ORL-1 pourvu d'une meilleure stabilité métabolique et d'une sélectivité plus forte et plus élevée que celle des composés classiques. L'agoniste des récepteurs ORL-1 présente par conséquent une biodisponibilité améliorée. De façon spécifique, l'invention porte sur un composé représenté par la formule générale (I). (I) (Dans la formule, les symboles sont tels que définis dans la description).

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