C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/06 (2006.01) A61K 31/4184 (2006.01) A61P 3/00 (2006.01) C07D 235/08 (2006.01) C07D 235/10 (2006.01)
Patent
CA 2710461
This invention relates generally to benzimidazole-based modulators of Liver X receptors (LXRs) and related methods (Formula I). wherein R2 is C6-C10 aryl or heteroaryl including 5-10 atoms, each of which is: (i) substituted with 1 R7, and (ii) optionally substituted with from 1-5 Re; and R1, R3, R4, R5, R6, R7, and Re are defined herein.
L'invention concerne de manière générale des modulateurs à base de benzimidazole de récepteurs hépatiques X (RHX), et des procédés relatifs (formule I), R2 étant un groupe aryle en C6-C10 ou hétéroaryle comprenant de 5 à 10 atomes, chacun étant : (i) substitué avec 1 R7, et (ii) facultativement substitué avec de 1 à 5 Re ; et R1, R3, R4, R5, R6, R7, et Re sont définis ici.
Bernotas Ronald Charles
Kaufman David Harry
Travins Jeremy Mark
Wrobel Jay E.
Torys Llp
Wyeth Llc
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