Benzimidazole compounds and medicaments comprising the same

Details Benzimidazole compounds and medicaments comprising the same Benzimidazole compounds and medicaments comprising the same

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4184 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/45 (2006.01) A61K 31/5377 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2377230

A benzimidazole compound or a salt thereof which has an inhibitory action of forming of macrophages and is useful as an active ingredient of a medicament for preventive and/or therapeutic treatment of arteriosclerosis, which is represented by the formula (I): (see formula I) wherein, R1 represents a functional group on the benzene ring selected from the group consisting of hydrogen atom, a halogen atom, a lower alkyl group and a lower alkoxy group; R2 represents hydrogen atom, an alkyl group or an acyl group; R3 represents a functional group on the ring containing the nitrogen atom and Z; Z represents a divalent group which forms a 5- or 6-membered ring; L represents a C4-C8 alkylene group or an ethyleneoxy linking group represented by (CH2CH2O)n CH2CH2 wherein n represents 1 or 2; and X represents O or S.

L'invention concerne des composés correspondant à la formule générale (I) ou leurs sels, présentant une activité inhibitrice de la conversion de macrophages en cellules spumeuses et utile comme principe actif de médicaments utilisés pour prévenir et traiter l'artériosclérose: (I). Dans la formule de la présente invention R1 représente un substituant sur l'anneau benzénique choisi parmi le groupe comprenant hydrogène, halogène, alkyle inférieur et alcoxy inférieur; R<2> représente hydrogène, alkyle, ou acyle; et R<3> représente un substituant sur l'anneau contenant de l'azote et Z; Z représente un groupe bivalent constitué de 5 ou 6 chaînons; L représente un alkylène en C4-C8 ou un groupe oxy-éthylène représenté par la formule générale: (CH2CH2O) nCH2CH2 (dans laquelle n représente 1 ou 2); et X représente O ou S.

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