Benzimidazole compounds and their use

C - Chemistry – Metallurgy – 07 – D

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C07D 235/04 (2006.01) A61K 31/395 (2006.01) C07D 235/08 (2006.01) C07D 235/18 (2006.01) C07D 235/28 (2006.01) C07D 235/30 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2025849

72222-154 ABSTRACT Certain benzimidazole compounds and their pharma- ceutically acceptable salts, are dual inhibitors of lipoxygenase and cyclooxygenase enzymes, and so are useful as antiallergy and antiinflammatory agenks. Image wherein R1 is H, -NH-R3, Image R3, -OR3, -SR3, -alkylene-R3 or R4, R3 is carboxyl, loweralkyl, loweralkoxy, loweralkoxycar- bonyl, aryl or heterocyclic, which may be substituted, R4 is aryl or heterocyclic, which may be substituted, R2 is aryl or heterocyclic, which may be substituted, A is H or halo, and m is an integer of 1 to 6.

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