Benzimidazole compounds and their use as estrogen...

Details Benzimidazole compounds and their use as estrogen... Benzimidazole compounds and their use as estrogen...

C - Chemistry, Metallurgy

07

D

C07D 235/08 (2006.01) A61K 31/4164 (2006.01) A61K 31/4184 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/425 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 38/27 (2006.01) A61K 45/06 (2006.01) A61P 19/10 (2006.01) C07D 235/18 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2487266

Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein at least one of R1 and R2 is a group of the formula (II), wherein R7, R8, R10 and R11 are each independently hydrogen; hydroxy; (C1-C6) alkyl; (C1- C6) alkoxy; or halogen; R9 is hydroxy; (C1-C6) alkoxy; (C1- C6)alkoxycarbonyloxy; (C1-C6)alkylcarbonyloxy; (C3-C8)cycloalkoxy; (C4- C8)cycloalkenyloxy; or (C6-C12) aryloxy; are useful as estrogen agonists and/or antagonists and pharmaceutical uses thereof.

L'invention se rapporte à des composés, notamment à des benzimidazoles, qui sont utiles en tant qu'agonistes et/ou antagonistes des oestrogènes ainsi qu'aux utilisations pharmaceutiques de ces composés. La présente invention se rapporte également à des benzimidazoles qui sont sélectifs vis-à-vis du récepteur ER.beta. ainsi qu'à leurs utilisations pharmaceutiques.

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