Benzimidazole compounds as orl1-receptor agonists

Details Benzimidazole compounds as orl1-receptor agonists Benzimidazole compounds as orl1-receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/454 (2006.01) A61K 31/46 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/541 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 451/02 (2006.01) C07D 471/04 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2330092

A compound of the formula: (see formula I) or a pharmaceutically acceptable salt thereof, wherein R1 is unsubstituted, mono-, di- or tri-substituted (C3-C11)cycloalkyl or (C3-C11)cycloalkenyl or the like, A is unsubstituted (C1-C7)alkyl or (C2-C5)alkenyl, hydroxy-(C1-C4)alkyl, (C1- C4)alkoxy- (C=O),or unsubstituted, mono-, di- or tri- substituted aryl, or aromatic- heterocyclic or the like, M is a covalent bond O, S, NH or the like, Y is 4- to 12-membered bicyclic- carbocyclic rings or 4- to 12-membered bicyclic-heterocyclic rings, or 5- to 17 membered spirocarbocyclic rings or 5- to 17-membered spiroheterocyclic rings or the like, Z1, Z2, Z3 and Z4 are hydrogen or the like, is disclosed. These compounds have ORL1-receptor agonist activity, and are thus useful as analgesics or the like in mammalian subjects.

Affiliated with

Also associated with

Rating

Benzimidazole compounds as orl1-receptor agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzimidazole compounds as orl1-receptor agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzimidazole compounds as orl1-receptor agonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1837399