Benzimidazole derivative

Details Benzimidazole derivative Benzimidazole derivative

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/4184 (2006.01) A61P 3/14 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2396908

Benzimidazole derivatives of the general formula (1) or medically acceptable salts thereof, being useful as clinically applicable human chymase depressants, wherein R1 and R2 are each hydrogen, alkyl, alkoxy, or the like; A is alkylene or alkenylene; E is -COOR3, -SO3R3, -CONHR3, -SO2NHR3, or the like; G is alkylene; M is a single bond or -S(O)m-; J is heteroaryl; and X is - CH= or nitrogen.

L'invention concerne des dérivés benzimidazoles correspondant à la formule générale (1), ou des sels de ceux-ci, acceptables médicalement, ces dérivés et sels étant utiles en tant que dépresseurs de chymases humaines et pouvant être cliniquement employés. Dans la formule (1), R?1¿ et R?2¿ représentent chacun hydrogène, alkyle, alcoxy ou analogue, A représente alkylène ou alcénylène, E représente -COOR?3¿, -SO¿3?R?3¿, -CONHR?3¿, -SO¿2?NHR?3¿, ou analogue, G représente alkylène, M représente une liaison simple ou -S(O)¿m?-, J représente hétéroaryle et X représente -CH= ou azote.

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