Benzimidazole derivatives

Details Benzimidazole derivatives Benzimidazole derivatives

C - Chemistry, Metallurgy

07

D

260/266.5

C07D 403/06 (2006.01) C07D 235/06 (2006.01) C07D 235/10 (2006.01) C07D 295/12 (2006.01)

Patent

CA 1065866

ABSTRACT OF THE DISCLOSURE A benzimidazole derivative of the formula Image (I), which has anti-inflammatory activity, and wherein R1 represents an ortho-hydroxyphenyl group, a para-chlorophenyl group or a para-fluorophenyl group; and R2 represents an alkyl group containing 2 to 4 carbon atoms, is produced, for example, by condensing a compound of the general formula Image (II), wherein R3 represents an ortho-hydroxypheny1 group, an ortho- acyloxyphenyl group, an ortho-benzyloxyphenyl group, a para- chlorobenzyl group or a para-fluorophenyl group, and X represents a halogen atom, an alkyl-sulphonyloxy group or an aryl-sulphonyl- oxy group, with an N-alkyl-piperazine of the general formula Image in which R2 has the above meaning.

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