Benzimidazole derivatives

Details Benzimidazole derivatives Benzimidazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 235/04 (2006.01) A61K 31/4184 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/5375 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 209/08 (2006.01) C07D 235/08 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 417/06 (2006.01) C07D

Patent

CA 2241186

Novel benzimidazole derivatives represented by the formula (I): (see formula I) wherein R, is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceutically acceptable salts. Because of their blood sugar-depressing effect or PDE5 inhibitory effect, these compounds or salts thereof are useful as medicines for treating impaired glucose tolerance, diabetes, diabetic complications, syndrome of insulin resistance, hyperlipidemia, atherosclerosis, cardiovascular disorders, hyperglycemia, or hypertension; or stenocardia, hypertension, pulmonary hypertension, congestive heart failure, glomerulopathy, tubulointerstitial disorders, renal failure, atherosclerosis, angiostenosis, distal angiopathy, cerebral apoplexy, chronic reversible obstructions, allergic rhinitis, urticaria, glaucoma, diseases characterized by enteromotility disorders, impotence, diabetic complications, nephritis, cancerous cachexia, or restenosis after PTCA.

L'invention porte sur de nouveaux dérivés du benzimidazole, ou leurs sels pharmacocompatibles, de formule (I) dans laquelle R3 représente carboxy, carboxy estérifié, carboxamide, amino, amido ou sulfonyle. De par leurs effets hypoglycémiants ou inhibiteurs du PDE5, ces composés ou leurs sels peuvent servir à traiter: une intolérance au glucose, le diabète et ses complications, le syndrome de résistance à l'insuline, l'hyperlipidémie, l'athérosclérose, les maladies cardio-vasculaires, l'hyperglycémie, l'hypertension, l'angine de poitrine, l'hypertension pulmonaire, l'insuffisance cardiaque globale, les troubles glomérulaires, les maladies tubulo-interstitielles, l'insuffisance rénale chronique, l'angiosténose, les troubles vasculaires périphériques, l'apoplexie, les maladies obstructives chroniques réversibles, la rhinite allergique, l'urticaire, le glaucome, les troubles de la motilité intestinale, l'impuissance sexuelle, les néphrites, la cachexie cancéreuse et les resténoses post opératoires.

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