Benzimidazole derivatives

Details Benzimidazole derivatives Benzimidazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4433 (2006.01) A61K 31/4439 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2690953

The present invention relates to a compound of the Formula I (1) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3A, R3B, R4, R5, X, m, and n are as defined herein. Such novel benzamidazole derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

La présente invention concerne un composé de formule I (I) ou un de ses sels pharmaceutiquement acceptables, dans laquelle R1, R2, R3A, R3B, R4, R5, X, m et n sont tels que définis dans le présent document. De tels nouveaux dérivés de benzamidazole sont utiles dans le traitement de la croissance cellulaire anormale, telle que le cancer, chez les mammifères. L'invention concerne également un procédé d'utilisation de tels composés dans le traitement de la croissance cellulaire anormale chez les mammifères, notamment les humains, et des compositions pharmaceutiques qui contiennent de tels composés.

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