Benzimidazole derivatives

Details Benzimidazole derivatives Benzimidazole derivatives

C - Chemistry, Metallurgy

07

D

260/242.01

C07D 487/04 (2006.01) C07D 235/30 (2006.01) C07D 491/04 (2006.01) C07D 491/14 (2006.01)

Patent

CA 1086727

ABSTRACT OF THE DISCLOSURE The invention concerns 3,4-tetrahydropyrimido [1,2-a] benzimidazole derivatives bearing one or more substituents at positions 6, 7, 8 or 9; processes for their preparation and manufacture; and pharmaceutical compositions thereof. The compounds inhibit the aggregation of blood-platelets and may be used in vivo, in the treatment or prophylaxis of thrombosis or occlusive vascular disease, or in vitro,in helping to stabilise preparations of blood platelets. Representative compounds of the invention are 7- and 8- acetyl-3,4-dihydropyrimido[1,2-a]benz- imidazol-2(1H)-one.

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