Benzimidazole derivatives and their use as kdr protein...

Details Benzimidazole derivatives and their use as kdr protein... Benzimidazole derivatives and their use as kdr protein...

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/4184 (2006.01) A61P 35/00 (2006.01) C07D 235/00 (2006.01) C07D 319/00 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2466813

The invention concerns novel products of formula (IA), wherein: A represents an optionally substituted cyclic or bicyclic saturated heterocycle, in particular pyrazole or imidazole, optionally substituted; A1, A2, A3 and A4, identical or different, are in particular selected among hydrogen, halogen, hydroxyl, alkyl and alkoxy, nitro, cyano, phenyl, phenoxy, free carboxy, salified, esterified by an alkyl radical or amidified to form CONA6A7 cyclized or not, with two among A1b, A2b, A3b and A4b capable of forming with the benzimidazole radical a cycle containing one or several heteroatoms; A5 represents hydrogen or alkyl, said products being in all isomeric forms and the salts as medicines in particular KDR inhibitors.

L'invention concerne les nouveaux produits de formule (IA) avec A représente un hétérocycle saturé monocyclique ou bicyclique éventuellement substitué, A1, A2, A3 et A4 identiques ou différents sont choisis notamment parmi hydrogène, halogène, hydroxyle, alkyle et alcoxy, nitro, cyano, phényle, phénoxy, carboxy libre, salifié, estérifié par un radical alkyle ou amidifié pour former - CONA6A7 cyclisé ou pas,avec deux parmi A1b, A2b, A3b et A4b peuvent former avec le radical benzimidazole un cycle renfermant un ou plusieurs hétéroatomes, A5 représente hydrogène ou alkyle, ces produits étant sous toutes les formes isomères et les sels, ô titre de médicaments notamment comme inhibiteurs de KDR.

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