Benzimidazole derivatives as calcium channel blockers

Details Benzimidazole derivatives as calcium channel blockers Benzimidazole derivatives as calcium channel blockers

C - Chemistry, Metallurgy

07

D

C07D 235/14 (2006.01) A61K 31/4184 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2722067

The invention relates to compounds of formula (I) wherein R1 represents aryl, which is unsubstituted, or mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4alkyl, (C1-4)alkoxy, halogen, and trifluoromethyl; R2 represents hydrogen, or -CO-R21; R21 represents (C1-5)alkyl, (C1-3)fluoroalkyl, or (C3-6)cycloalkyl; m represents the integer 2, or 3; p represents the integer 2 or 3; and R3 represents hydrogen, or (C1-5)alkyl; and pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.

L'invention porte sur des composés de formule (I), dans laquelle R1 représente un groupe aryle, qui est non substitué ou mono-, di- ou tri-substitué, les substituants étant indépendamment choisis dans le groupe constitué par un groupe alkyle en C1-4, alcoxy en C1-4, un halogène et un groupe trifluorométhyle ; R2 représente un atome dhydrogène ou CO-R21 ; R21 représente un groupe alkyle en C1-5, fluoroalkyle en C1-3 ou cycloalkyle en C3-6 ; m représente l'entier 2 ou 3 ; p représente l'entier 2 ou 3 ; et R3 représente un atome dhydrogène ou un groupe alkyle en C1-5 ; et les sels pharmaceutiquement acceptables de tels composés. Ces composés sont utiles en tant que bloqueurs des canaux calciques.

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