Benzimidazole derivatives as raf kinase inhibitors

Details Benzimidazole derivatives as raf kinase inhibitors Benzimidazole derivatives as raf kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2531859

The present invention relates to benzimidazole derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. Accordingly, the compound of Formula I or a pharmaceutically acceptable salt thereof is administered for the treatment of diseases mediated by one or more kinase pathways, preferably by the raf kinase pathway, especially cancers, [FORMULA]

L'invention concerne des dérivés de benzimidazoles de formule (I), l'utilisation des composés de formule (I) comme inhibiteurs d'une ou de plusieurs kinases, l'utilisation des composés de formule (I) pour produire une composition pharmaceutique et une méthode de traitement comprenant l'administration de ladite composition pharmaceutique à un patient. En conséquence, le composé de formule (I) ou un de ses sels pharmaceutiquement acceptables est administré dans le traitement de pathologies induites par un ou par plusieurs processus de kinase, de préférence par le processus de kinase Raf, notamment des cancers.

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