Benzimidazole derivatives as selective acid pump inhibitors

Details Benzimidazole derivatives as selective acid pump inhibitors Benzimidazole derivatives as selective acid pump inhibitors

C - Chemistry, Metallurgy

07

D

C07D 491/04 (2006.01) A61K 31/4188 (2006.01) A61P 1/04 (2006.01) A61P 1/08 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2657550

Abstract This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1, R2, R3, R4, A and E are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zolli.pi.ger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, cancer, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.

Cette invention concerne les composés de formule (I) : (I) ou un sel pharmaceutiquement acceptable de ces composés, où R1, R2, R3, R4, A et E sont chacun tels que décrits dans le présent document ou un sel pharmaceutiquement acceptable, et les compositions contenant ces composés et le procédé de traitement et l'utilisation, comprenant ces composés en vue du traitement d'un état induit par l'activité antagoniste de la pompe à protons tel que, mais sans y être limité, une maladie gastro-intestinale, une maladie gastro-AEsophagienne, un reflux gastro-AEsophagien (RGO), un reflux laryngo-pharyngé, un ulcère gastro-duodénal, un ulcère gastrique, un ulcère duodénal, les ulcères induits par AINS, une gastrite, une infection d'Helicobacter pylori, une dyspepsie, une dyspepsie fonctionnelle, le syndrome de Zollinger-Ellison, une maladie de reflux non inflammatoire (NERD), une douleur viscérale, un cancer, un pyrosis, une nausée, une AEsophagite, une dysphagie, une hypersalivation, des troubles des voies respiratoires ou de l'asthme.

Affiliated with

Also associated with

Rating

Benzimidazole derivatives as selective acid pump inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzimidazole derivatives as selective acid pump inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzimidazole derivatives as selective acid pump inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1919341