Benzimidazole derivatives as sirtuin modulators

Details Benzimidazole derivatives as sirtuin modulators Benzimidazole derivatives as sirtuin modulators

C - Chemistry, Metallurgy

07

D

C07D 235/18 (2006.01) A61K 31/4184 (2006.01)

Patent

CA 2617557

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

L~invention concerne de nouveaux composés modulant le sirtuin et leurs méthodes d~utilisation. Les composés modulant le sirtuin peuvent être utilisés pour augmenter la durée de vie d'une cellule, et traiter et/ou empêcher une grande variété de maladies et de troubles y compris, par exemple, des maladies ou troubles en rapport avec le vieillissement ou le stress, le diabète, l~obésité, des maladies neurodégénératives, des maladies cardio-vasculaires, des troubles de la coagulation du sang, l~inflammation, le cancer, et/ou des bouffées vasomotrices ainsi que des maladies ou troubles qui seraient améliorés par une activité mitochondriale augmentée. Elle concerne aussi des compositions qui comprennent un composé modulant le sirtuin en combinaison avec un autre agent thérapeutique.

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