Benzimidazole derivatives having dopaminergic activity

Details Benzimidazole derivatives having dopaminergic activity Benzimidazole derivatives having dopaminergic activity

C - Chemistry, Metallurgy

07

D

C07D 235/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 235/06 (2006.01) C07D 235/26 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2196769

The present invention provides compounds of the Formula (I): (see formula I) Image (wherein, preferably, X is nitrogen or carbon; R1 is a substituted phenyl; one of R2 and R3 is hydroxy and the other is hydrogen or (C1-C6)alkyl; R4 is hydrogen or (C1-C6) alkyl; R5, R6 and R7 are independently halo or hydrogen; R8, R9 and R10 are independently hydrogen or (C1-C6)alkyl; R11 is hydrogen or is absent if the five-membered ring contains a double bond; R15 and R16 are hydrogen; and R17 is hydrogen or methyl); with the proviso that when X is nitrogen and is double bonded to an adjacent ring carbon atom, R1 is absent. These compounds exhibit central dopaminergic activity and are useful in the treatment of CNS disorders.

L'invention concerne de nouveaux dérivés de benzimidazole pharmaceutiquement actifs, de la formule (I), dans laquelle la ligne en pointillé, X et les groupes R<1> à R<7>, R<11> et R<15> à R<17> correspondent à la définition donnée dans la description. Ces composés présentent une activité dopaminergique centrale et sont utiles dans le traitement de troubles du système nerveux central.

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