Benzimidazole derivatives, their preparation and use, and...

Details Benzimidazole derivatives, their preparation and use, and... Benzimidazole derivatives, their preparation and use, and...

C - Chemistry, Metallurgy

07

D

260/304, 260/305

C07D 235/18 (2006.01) C07D 303/22 (2006.01) C07D 317/58 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1146563

ABSTRACT OF THE DISCLOSURE A derivative of benzimidazole of the general formula I : Image I wherein R1 represents a linear or ramified alkyl radical C1,C2,C3,C4, C5,C6,C7,C8,C9,C10,C11,C12,C13,C14,C15,C16,C17 or C18, a cyclo- alkyl radical C3,C4,C5,C6,C7 or C8, a linear or ramified alkyl radical C1,C2,C3,C4 or C5 substituted by one or more radicals selected from the group comprising : - phenyl, phenoxy, phenylthio, phenylsufinyl radicals, - phenyl, phenoxy, phenylthio, phenylsulfinyl radicals substi- tuted by one or more linear or ramified alkyl radicals C1,C2, C3 or C4, by one or more linear or ramified alkoxy radicals C1,C2, C3 or C4, by a methylenedioxy radical. or one or more halogen atoms, such as fluorine, chlorine or bromine; - linear or ramified alkylcarboxamido groups C1,C2,C3,C4,C5 or C6 optionally substituted by a phenyl or phenoxy radical; - cycloalkylcarboxamido groups C1,C4,C5,C6,C7 or C8, R2 repre- sents hydrogen, one or more linear or ramified alkyl radicals C1.C2,C3 a C4, one or more linear or ramified alkoxy radicals C1,C2,C3 or C4, one or more halogen atoms, such as fluorine, chlorine and bromine, R3 represents hydrogen, one or more li- near or ramified alkyl radicals C1,C2,C3 or C4, one or more linear or ramified alkoxy radicals C1,C2,C3 or C4, one or more halogen atoms such as fluorine, chlorine and bromine, one or more nitro groups, as well an esters and salts of such deriva- tives with non toxical and pharmaceutically acceptable acids. Such compounds have activities on the cardiovascular system and/or on the central nervous system.

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