Benzimidazole derivatives, their production and use

Details Benzimidazole derivatives, their production and use Benzimidazole derivatives, their production and use

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) C07D 235/24 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07F 9/6506 (2006.01)

Patent

CA 2204290

Benzimidazole derivatives of the formula (I): (see fig.I) (I) wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R1 is hydrogen or an optionally substituted hydrocarbon residue; R2 is a group capable of forming an anion or a group convertible thereinto; X is a direct bond or a spacer having an atomic length of two or less between the phenylene group and the phenyl group; R' is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or convertible to an anion; Y is -O-, -S(O)m- or -N(R~)- wherein m is an integer of 0, 1 or 2 and R~ is hydrogen or an optionally substituted alkyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.

Dérivés de benzimidazole de formule (I) (voir fig. I), où le cycle A est un noyau benzénique qui peut facultativement comporter de la substitution en plus du groupe R'; R1 est de l'hydrogène ou un résidu d'hydrocarbure facultativement substitué; R2 est un groupe pouvant former un anion ou un groupe convertible en anion; X est une liaison directe ou un séparateur possédant une longueur atomique de deux ou moins entre le groupe phénylène et le groupe phényle; R' est un carboxyle, un ester ou un amide de ce carboxyle, ou un groupe pouvant former un anion ou convertible en un anion; Y est -O-, -S(O)m- ou -N(R~)- où m est l'entier 0, 1 ou 2 et R~ est de l'hydrogène ou un groupe alkyle substitué facultativement; n est l'entier 1 ou 2; leurs sels, acceptables en pharmacie, possèdent une activité potentielle antagoniste d'angiotensine II et une activité d'antihypertenseur, ce qui les rend utiles comme agents thérapeutiques pour le traitement des maladies du système circulatoire, notamment des troubles d'hypertension, des maladies cardiaques (p. ex.hypercardie, insuffisance cardiaque, infarctus, etc.), des attaques, de l'apoplexie cérébrale, de la néphrite, etc.

Affiliated with

Also associated with

Rating

Benzimidazole derivatives, their production and use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzimidazole derivatives, their production and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzimidazole derivatives, their production and use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2039922