Benzimidazole derivatives used as fxr agonists

Details Benzimidazole derivatives used as fxr agonists Benzimidazole derivatives used as fxr agonists

C - Chemistry, Metallurgy

07

D

C07D 235/12 (2006.01) A61K 31/4184 (2006.01) A61K 31/4402 (2006.01) A61P 1/16 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2697167

The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 and X are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.

L'invention porte sur de nouveaux dérivés de benzimidazole substitués de formule (I), dans laquelle R1 à R10 et X sont tels que définis dans la description et les revendications, ainsi que sur les sels et esters de celui-ci physiologiquement acceptables. Ces composés se lient au récepteur FXR et peuvent être utilisés comme médicaments.

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