C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/06 (2006.01) A61K 31/4184 (2006.01) A61P 1/04 (2006.01) A61P 13/10 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2660529
The claimed invention provides benzimidazole derivatives antagonists of VR1, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds of Formula I may be used in the treatment of osteoarthritis, chronic tendinitis, pelvic pain and peripheral neuropathy, gastroesophageal reflux disease, irritable bowel syndrome and overactive bladder.
La présente invention concerne des dérivés de benzimidazole antagonistes du VRl, leurs procédés de préparation, des compositions pharmaceutiques qui les contiennent et leur utilisation thérapeutique. Les composés de formule (I) peuvent être utilisés pour le traitement de l'arthrose, de la tendinite chronique, de la douleur pelvienne et de la neuropathie périphérique, du reflux gastro-AEsophagien, de la colopathie fonctionnelle et de la vessie hyperactive. Formule (I)
Brown William
Johnstone Shawn
Labrecque Denis
Astrazeneca Ab
Fetherstonhaugh & Co.
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