A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/28 (2006.01) A61K 31/4439 (2006.01)
Patent
CA 2614526
A dry manufacturing process for the production of a pharmaceutical formulation of a benzimidazole and an alkaline substance is described. A tablet is compressed directly from a dry powder or a dry particulate matter avoiding any liquid or excipient conventionally used as a wet binder. The manufacturing process has the advantage of being simple and cost efficient. At the same time an expensive drying step is superfluous. The resulting pharmaceutical formulation has a good stability and a good dissolution profile.
L'invention concerne un procédé de fabrication à sec destiné à la production d'une formulation pharmaceutique d'un benzimidazole et d'une substance alcaline. Un comprimé est comprimé directement à partir d'une poudre sèche ou d'une substance particulaire sèche, contournant ainsi l'utilisation d'un liquide ou excipient quelconque généralement utilisé comme liant humide. Le procédé de fabrication présente un caractère avantageux en ce qu'il est simple et rentable, une étape de séchage onéreuse étant superflue. La formulation pharmaceutique obtenue présente une bonne stabilité et un bon profil de dissolution.
Bertelsen Poul
Olsen Peder Mohr
Gowling Lafleur Henderson Llp
Nycomed Danmark Aps
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