Benzimidazole phosphono-amino acids

Details Benzimidazole phosphono-amino acids Benzimidazole phosphono-amino acids

C - Chemistry, Metallurgy

07

F

C07F 9/6506 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2080253

AHP-9836 BENZIMIDAZOLE PHOSPHONO-AMINO ACIDS Abstract of the Disclosure The compounds of the formula Image wherein R is hydrogen, lower alkyl, benzyl or pivaloyloxymethyl; R1 and R2 are, independently, hydrogen, lower alkyl, lower alkoxy, trifluoromethyl, trifluoromethoxy, methanesulfonylamino, acetylamino, or halo, or when taken together R1 and R2 represent a methylenedioxy grouping; and the pharmacologically acceptable salts thereof are NMDA antagonists useful in the treatment and prevention of central nervous system related pathological conditions resulting from overstimulation by excitatory amino acids.

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