Benzimidazole quinolinones and uses thereof

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/4375 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/52 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 453/02 (2006.01) C07D 453/06 (2006.01)

Patent

CA 2496164

Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.

L'invention concerne des procédés permettant d'inhiber différentes enzymes ainsi que de traiter différents états. Ces procédés consistent entre autres à administrer à un sujet un composé de structure (I) ou (IB), un sel pharmaceutiquement acceptable de ce composé, un tautomère de ce composé ou un sel pharmaceutiquement acceptable de ce tautomère. Cette invention se rapporte en outre à des composés de structure (I) et (IB) dont les variables sont telles que définies dans la description. Lesdits composés peuvent être employés pour préparer des médicaments servant à inhiber différentes enzymes ainsi qu'à traiter des états dont la médiation est assurée par de telles enzymes.

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