Benzimidazoles and analogs as rho kinase inhibitors

Details Benzimidazoles and analogs as rho kinase inhibitors Benzimidazoles and analogs as rho kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2709883

Compounds useful as Rho kinase inhibitors according to formula IA or IB: wherein A, B, D, E, R1, R2 and Ar1 are as defined herein, and any tautomer, salt, stereoisomer, hydrate, solvent, or prodrug thereof, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.

L'invention porte sur des composés utiles comme inhibiteurs de la Rho-kinase selon la formule IA ou IB : formules dans lesquelles A, B, D, E, R1, R2 et Ar1 sont définis dans la demande, et sur tout tautomère, sel, stéréoisomère, hydrate, solvant ou pro-médicament de ceux-ci, sur des compositions pharmaceutiques, sur des procédés de traitement et sur des procédés de synthèse.

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