Benzimidazoles and imidazopyridines as respiratory syncytial...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/06 (2006.01) A61K 31/4184 (2006.01) A61K 31/4188 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61P 31/14 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2376781

This invention concerns the use of compounds of formula (I) wherein -a1=a2- a3=a4- is a radical of formula -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, - CH=CH-N=CH-, -CH=CH-CH=N- wherein each hydrogen atom may optionally be substituted; Q is a radical of formulas (b-1), (b-2), (b-3), (b-4), (b-5), (b- 6), (b-7), (b-8), G is a direct bond or C1-10alkanediyl; R1 is an optionally substituted monocyclic heterocycle; for the manufacture of a medicament for the treatment of viral infections, in particular RSV infections. Certain compounds of formula (I) are new.

La présente invention concerne des composés représentés par la formule (I), dans laquelle -a1=a2-a3=a4- représente un radical de formule -CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-N=CH-; -CH=CH-CH=N- où chaque atome d'hydrogène peut être éventuellement substitué; Q est un radical représenté par une des formules (b-3), (b-4), (b-5), (b-6), (b-7) et (b-8); G est une liaison directe ou alkanediyle C¿1-10?; R?1¿ est un hétérocycle monocyclique éventuellement substitué. L'invention se rapporte notamment à l'utilisation de ces composés pour la fabrication d'un médicament destiné au traitement des infections virales, et notamment des infections à virus respiratoire syncytial (RSV). Certains des composés représentés par la formule (I) sont des composés nouveaux.

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