Benzimidazoles and related analogs as sirtuin modulators

Details Benzimidazoles and related analogs as sirtuin modulators Benzimidazoles and related analogs as sirtuin modulators

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 471/08 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2729128

Provided herein are sirtuin-modulating compounds of formula (II). The sirtuin- modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

L'invention concerne des composés modulateurs de sirtuine de la formule (II). Les composés modulateurs de sirtuine peuvent être utilisés pour augmenter la durée de vie d'une cellule, et pour traiter et/ou prévenir une large variété de maladies et de troubles comprenant par exemple des maladies ou troubles associés au vieillissement ou au stress, le diabète, l'obésité, des maladies neurodégénératives, des maladies cardiovasculaires, des troubles de la coagulation du sang, une inflammation, le cancer et/ou des bouffées vasomotrices, ainsi que des maladies ou des troubles qui bénéficieraient dune activité mitochondriale accrue. L'invention concerne également des compositions comportant un composé modulateur de sirtuine en combinaison avec un autre agent thérapeutique.

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