Benzimidazoles, pharmaceutical compositions containing these...

Details Benzimidazoles, pharmaceutical compositions containing these... Benzimidazoles, pharmaceutical compositions containing these...

C - Chemistry, Metallurgy

07

D

C07D 403/02 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 235/04 (2006.01) C07D 235/08 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2047496

The invention .relates to benzimidazoles of formula I (see formula I) their 1-, 3-isomer mixtures, and the salts thereof, wherein the substituents R1, R2, R3 and R4 are preferably as follows: R1 in the 6-position represents a 1-methylbenzimidazol- 2-yl, 3,4,5,6-tetrahydro-phthalimino, 2,3-diphenyl-maleic acid imido, 2,3-dimethyl-maleic acid imido, N-phenylmethanesulphonyl.-methylamino, 2-oxo-pyrrolidin-1-yl, 2-oxo-piperidin-1-yl, 2-oxo-hexamethyleneimino, 2-oxo-3, 4-tetramethylene-pyrrolidin-2-yl, 3,3-dimethylglutarimido, N-methylaminocarbonyl-n-pentylamino, propanesultam-1-yl or butanesultam-1-yl group; R2 represents a methyl, ethyl, n-propyl or n-butyl group; R3 represents a carboxy or 1H-tetrazolyl group; and R4 represents a hydrogen atom. These compounds have valuable properties, in particular as angiotensin-II antagonists.

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