Benzimidazolidinone derivatives as muscarinic agents

Details Benzimidazolidinone derivatives as muscarinic agents Benzimidazolidinone derivatives as muscarinic agents

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/454 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01) C07D 209/32 (2006.01) C07D 235/26 (2006.01) C07D 263/58 (2006.01) C07D 277/68 (2006.01) C07D 451/02 (2006.01)

Patent

CA 2457647

Benzimidazolidinone derivative compounds, which increase acetylcholine signalling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.

L'invention concerne des composés dérivés de benzimidazolidinone qui provoquent une augmentation de la signalisation de l'acétylcholine ou de son effet dans le cerveau, ainsi que des agonistes muscariniques fortement sélectifs, en particulier pour les sous-types de récepteurs M1 et/ou M4. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que des méthodes de traitement de la psychose au moyen de ces composés.

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