C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/454 (2006.01) A61K 31/46 (2006.01) A61K 31/517 (2006.01) A61P 25/00 (2006.01) C07C 251/20 (2006.01) C07D 451/04 (2006.01)
Patent
CA 2539566
The invention relates to a group of novel benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these imidazolone and quinazolinone derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1): wherein the symbols have the meanings as given in the description.
L'invention concerne un groupe de nouveaux dérivés de benzimidazolone et de quinazolinone qui sont des agonistes sur des récepteurs ORL1 humains (nociceptine). L'invention concerne également la préparation de ces composés, les compositions pharmaceutiques contenant une quantité active sur le plan pharmacologique d'au moins un de ces dérivés d'imidazolone et de quinazolinone en tant que principe actif, ainsi que l'utilisation de ces compositions pharmaceutiques dans le traitement de troubles dans lesquels les récepteurs ORL1 sont impliqués. L'invention concerne enfin des composés représentés par la formule générale (1), dans laquelle les symboles ont les significations figurant dans la description.
Den Hartog Jacobus A. J.
Terpstra Jan-Willem
Tuinstra Tinka
Van Scharrenburg Gustaaf J. M.
Van Stuivenberg Herman H.
Fetherstonhaugh & Co.
Solvay Pharmaceuticals B.v.
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