C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4184 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2569654
This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.
L'invention concerne des composés ayant la formule (I) dans laquelle R1, R2, R3, A et m sont chacun décrits dans la description, ou un sel ou un solvate pharmaceutiquement acceptable, et des compositions contenant ces composés ainsi que leur utilisation dans le traitement d'un état à médiation par une activité de récepteur 5-HT4 tel que (mais de façon non restrictive) le reflux gastro-oesophagien, la maladie gastro-intestinale, le trouble de motilité gastrique, la dyspepsie non ulcéreuse, la dyspepsie fonctionnelle, le syndrome de côlon irritable, la constipation, la dyspepsie, l'oesophagite, la maladie gastro-oesophagien, la nausée, la maladie du système nerveux central, la maladie d'Alzheimer, le trouble cognitif, le vomissement, la migraine, le trouble neurologique, la douleur, des troubles cardiovasculaires tels que l'insuffisance cardiaque et l'arythmie, le diabète et le syndrome d'apnée.
Ando Koji
Iguchi Satoru
Murase Noriaki
Murata Yoshinori
Numata Toyoharu
Pfizer Inc.
Torys Llp
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