C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/4184 (2006.01) A61P 1/04 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2537127
This invention provides a compound of the formula (I) or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.
L'invention concerne un composé de formule (I) ou un de ses sels pharmaceutiquement acceptables, ainsi que des compositions qui contiennent ces composés et l'utilisation de ces composés pour préparer des médicaments de traitement du reflux gastro-oesophagien pathologique, des maladies gastro-intestinales, des troubles de la motilité gastrique, de la dyspepsie non ulcéreuse, de la dyspepsie fonctionnelle, du côlon irritable, de la constipation, de la dyspepsie, de l'oesophagite, des maladies gastro-oesophagiennes, de la nausée, des maladies du système nerveux central, de la maladie d'Alzheimer, des troubles cognitifs, des vomissements, de la migraine, des maladies neurologiques, de la douleur, des troubles cardio-vasculaires, de l'insuffisance cardiaque, de l'arythmie cardiaque, du diabète et du syndrome d'apnée. Ces composés ont une activité d'agonistes du récepteur 5-HT¿4? et sont ainsi utiles pour traiter le reflux gastro-oesophagien pathologique, la dyspepsie non ulcéreuse, la dyspepsie fonctionnelle, le côlon irritable ou des états similaires chez des mammifères, surtout des êtres humains.
Iguchi Satoru
Katsu Yasuhiro
Kojima Takashi
Sone Hiroki
Uchida Chikara
Pfizer Inc.
Smart & Biggar
LandOfFree
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