Benzimidazolone derivatives and their use as...

Details Benzimidazolone derivatives and their use as... Benzimidazolone derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 235/26 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61P 15/10 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 235/28 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2379554

Compounds of formula (Ia) wherein Xa is CH or nitrogen, Ya is oxygen or sulfur, R1a and R2a are specific substituents, R3a, R4a and R5a are the same or different, hydrogen, halogen, cyano, lower alkoxy or lower-alkoxy- substituted aralkyl; or two of R3a, R4a and R5a may combine together to form lower alkylenedioxy, and m is 1 or 2, are useful as cGMP-PDE inhibitors.

La présente invention concerne des composés représentés par la formule générale et convenant comme inhibiteurs de la cGMP-PDE. En l'occurrence, X?a¿ est CH ou azote. Y?a¿ est oxygène ou soufre. R?1a¿ et R?2a¿ sont des substituants spécifiques. R?3a¿, R?4a¿ et R?5a¿ sont identiques ou différents, hydrogène, halogène, cyano, alcoxy inférieur ou aralkyle à substitution d'alcoxy inférieur. Mais il est également possible que deux des groupes R?3a¿, R?4a¿ et R?5a¿ se combinent ensemble pour former un alkylènedioxy inférieur. Enfin, m vaut 1 ou 2.

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