Benzimidazolones and their use as cytokine inhibitors

Details Benzimidazolones and their use as cytokine inhibitors Benzimidazolones and their use as cytokine inhibitors

C - Chemistry, Metallurgy

07

D

C07D 235/26 (2006.01) A61K 31/4184 (2006.01) A61K 31/497 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 471/10 (2006.01) C07D 491/10 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2498754

Disclosed are benzimidazolone compounds of formulas (II) wherein X is O, S or NR5. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

L'invention concerne des composés de benzimidazolone représentés par la formule (II), dans laquelle X représente O, S ou NR5. Ces composés inhibent la production des cytokines participant aux processus inflammatoires, et permettent par conséquent de traiter les maladies et les états pathologiques associés à une inflammation, comme par exemple les maladies inflammatoires chroniques. L'invention concerne également des procédés permettant de préparer ces composés ainsi que des compositions pharmaceutiques contenant ces composés.

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