Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

IPC codes

C07D 417/12 (2006.01) A61K 31/425 (2006.01)

Type

Patent

Patent number

CA 2186513

Description

This invention relates to new heterocyclic compounds which are selective inhibitors of 5-lipoxygenase (5-LO). The new heterocyclic compounds are useful in inhibiting 5-LO per se and in the treatment or alleviation of inflammatory disease or condition, allergy or cardiovascular diseases in mammals wherein the inflammatory disease or condition includes but is not limited to asthma, arthritis, bronchitis, chronic obstructive pulmonary disease, psoriasis, allergic rhinitis, dermatitis, shock, atopic dermatitis, rheumatoid arthritis or osteoarthritis. This invention also relates to pharmaceutical compositions useful therefor.

La présente invention concerne de nouveaux composés hétérocycliques qui sont des inhibiteurs sélectifs de la 5-lipoxygénase (5-LO). Ces nouveaux composés hétérocycliques servent à inhiber 5-LO per se ainsi qu'à traiter ou à atténuer des maladies ou états inflammatoires, des allergies ou des maladies cardiovasculaires chez les mammifères, les malaides ou états inflammatoires étant notamment - mais pas seulement - l'asthme, l'arthrite, la bronchite, la bronchopneumopathie chronique obstructive, le psoriasis, les rhinites allergiques, l'eczéma, l'état de choc, l'eczéma constitutionnel, la polyarthrite rheumatoïde ou l'arthrose. L'invention porte aussi sur des compositions pharmaceutiques utiles pour le traitement de ces maladies.

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