Benzisoxazole derivatives

Details Benzisoxazole derivatives Benzisoxazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/454 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2598516

This invention relates to compounds of the formula (I): wherein A, B, R1, R4, m, and n are each as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4, receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome. (see above formula)

L'invention concerne des composés de formule (I): dans laquelle A, B, R1, R4, m et n sont chacun tels que définis dans la description, ou un sel pharmaceutiquement acceptable de ceux-ci, ainsi que des compositions contenant ces composés et l'utilisation de ces composés dans le traitement d'un état induit par l'activité du récepteur 5-HT4, tel que, entre autres, la maladie du reflux gastro-oesophagien, les maladies gastro-intestinales, les troubles de la motilité gastrique, la dyspepsie non ulcéreuse, la dyspepsie fonctionnelle, le syndrome du côlon irritable, la constipation, la dyspepsie, l'oesophagite, les maladies gastro-oesophagiennes, les nausées, les maladies du système nerveux central, la maladie d'Alzheimer, les troubles cognitifs, les vomissements, la migraine, les maladies neurologiques, la douleur, les troubles cardio-vasculaires, tels que l'insuffisance cardiaque et l'arythmie cardiaque, le diabète et le syndrome d'apnée.

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