C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/38 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) C07C 251/48 (2006.01) C07D 211/00 (2006.01) C07D 213/61 (2006.01) C07D 261/00 (2006.01) C07D 261/20 (2006.01) C07D 333/00 (2006.01) C07D 333/56 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 491/10 (2006.01) C07D 498/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2383332
The compounds are of the class of benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives having the general Formula I: (see formula I) which are useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 receptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.
L'invention porte sur des composés de la classe des dérivés benzisoxazolyle, pyridoisoxazolyle et benzthiényle du propyle à substitution phénoxy utiles comme antagonistes du D4. Lesdits composés servent au traitement des états morbides médiés par l'inhibition du récepteur D4. Ces états comprennent par exemple: le déficit d'attention, les troubles d'hyperactivité, les névroses obséssionnelles-compulsives, les psychoses, les toxicomanies, la dépendance aux substances toxiques, la maladie de Parkinson, le parkinsonisme, la diskinésie tardive, le syndrome de Gilles de la Tourette, les troubles du comportement, et les troubles oppositionnels. Un autre aspect de l'invention porte sur des préparations pharmaceutiques, sur des intermédiaires, et sur un procédé d'obtention de cette classe de composés.
Freed Brian S.
Hanna Reda G.
Hendrix James A.
Hrib Nicholas J.
Jurcak John G.
Aventis Pharmaceuticals Inc.
Aventisub II Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1471999