C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/519 (2006.01)
Patent
CA 2527617
This invention relates to benzo (4, 5) thieno (2, 3-d) pyrimidin-4-one compounds, their 5,6-dihydro and 5, 6, 7, 8-tetrahydro derivatives and their use for the treatment of a steroid hormone dependent disease or disorder, preferably for a steroid hormone dependent disease or disorder requiring the inhibition of a 17-hydroxysteroid dehydrogenase enzyme, most preferably of the 17beta HSD type 1, type 2 or type 3 enzyme. The steroid hormone dependent disease of disorder is selected from the group consisting of breast cancer, prostate carcinoma, ovarioan cancer, uterine cancer, endometrial cancer and endometrial hyperplasia, endometriosis, uterine fibroids, uterine leiomyoma, adenomyosis, dysmenorrhea, menorrhagia, metrorrhagia, prostadynia, benign prostatic hyperplasia, prostatitis, acne, seborrhea, hirsutism, androgenic alopecia, precocious puberty, adrenal hyperplasia, polycystic ovarian syndrome, urinary dysfunction, osteoporosis, multiple sclerosis, rheumatoid arthritis, Alzheimer~s disease, colon cancer, tissue wounds, skin wrinkles and cataracts.
Cette invention se rapporte à de nouveaux dérivés thiophènepyrimidinone et à leur utilisation en thérapie, notamment dans le traitement et/ou la prévention des maladies ou des troubles dépendant de l'hormone stéroïde, tels que les maladies ou les troubles dépendant de l'hormone stéroïde nécessitant l'inhibition des enzymes 17.szlig.-hydroxystéroïdr-déshydrogénases.
Hirvelae Leena
Johansson Nina
Johnson Mark Stuart
Koskimies Pasi
Lehtovuori Pekka
Mccarthy Tetrault Llp
Solvay Pharmaceuticals B.v.
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