Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives as farnesyl...

Details Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives as farnesyl... Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives as farnesyl...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/435 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2293433

Novel compounds of formula (1.0), wherein a represents N or NO, R1 and R3 are halo, R2 and R4 are independently H or halo provided that at least one is H, X is C, CH or N, and T represents (i) wherein R5 is H(C1-C6)alkyl or a bond; b and c are independently 0 to 3 and Y is a three, four, five or six membered cycloalkyl ring, pyridyl, pyrazinyl or phenyl are disclosed. Pharmaceutical compositions containing such compounds, methods of inhibiting farnesyl protein transferase and methods for treating tumor cells using such compounds or compositions are also disclosed.

La présente invention concerne de nouveaux composés représentés par la formule (1.0) dans laquelle a est N ou NO, et R<1> et R<3> sont halo, R<2> et R<4> sont indépendamment H ou halo sous réserve qu'au moins un désigne H, X est C, CH ou N, et T désigne (i) où R5 est H (C1-C6)alkyle ou une liaison; b et c valent indépendamment entre 0 et 3 et Y désigne un composé cyclique cycloalkyle à 3, 4, 5, ou 6 chaînons, pyridyle, pyrazinyle, ou phényle. La présente invention concerne également des compositions pharmaceutiques contenant lesdits composés, des procédés d'inhibition de la transférase de protéine de farnesyl et des procédés de traitement de cellules tumorales utilisant lesdits composés ou compositions.

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