Benzo(5,6)cyclohepta(1,2-b)pyridine derivatives useful for...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/14 (2006.01) A61K 31/4545 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 493/08 (2006.01)

Patent

CA 2293368

Novel compounds of formula (1.0) are disclosed. In Formula (1.0) a represents N or NO, R1 and R3 are halo, R2 and R4 are independently H or halo provided that at least one is H, X is C, CH or N, and T represents a five or six membered heterocycloalkyl ring having one or two heteroatoms selected from S or O. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.

La présente invention concerne de nouveaux composés représentés par la formule (1.0) dans laquelle a est N ou NO; R<1> et R<3> sont halo; R<2> et R<4> sont indépendamment H ou halo à condition qu'au moins l'un d'eux représente H; X est C, CH, ou N; et R est un noyau hétérocycloalkyle à cinq ou six chaînons présentant un ou deux hétéroatomes sélectionnés dans le groupe constitué de S ou O. La présente invention concerne également des procédés d'inhibition de la farnésyl protéine transférase et des procédés de traitement de cellules tumorales.

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