C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/4418 (2006.01) A61K 31/444 (2006.01) A61K 31/5355 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2293711
Compounds of formula (I) (see formula I) useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed, or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, wherein: R and R2 are independently selected from halo; R1 and R3 are independently selected from the group consisting of H and halo, provided that at least one of R1 and R3 is H; R4 is formula (II) or R5; R5 is formula (III) (see formula III), (IV) (see formula IV), (V) (see formula V), (VI) (see formula VI), (VII) (see formula VII), (VIII) (see formula VIII), (IX) (see formula IX), (X) (see formula X) or (XI) (see formula XI); and the remaining variables are as defined in the specification.
La présente invention concerne des composés représentés par la formule (I) utilisés pour inhiber la fonction Ras et donc inhiber ou traiter la croissance anormale des cellules ainsi que leurs N-oxides, leurs sels ou leurs solvates pharmaceutiquement acceptables, dans laquelle R et R<2> sont indépendamment choisis parmi les halogènes; R<1> et R<3> sont indépendamment sélectionnés dans le groupe constitué de H et des halogènes, étant entendu qu'au moins R<1> ou R<3> est H; R<4> est (II) ou R<5>; R<5> est (III), (IV), (V), (VI), (VII), (VIII), (IX), (X) ou (XI), et les variables restant sont telles que définies dans la description.
Doll Ronald J.
Rane Dinanath F.
Remiszewski Stacy W.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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