C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/12 (2006.01) A61K 31/473 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2751892
The present invention provides compounds of formula I: formula (I) wherein X1- X4 and R1-R12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be useful for the treatment and/or prevention of bacterial infections. The in-vention also provides compositions comprising these compounds as well as methods for using these compounds to inhibit bacteri-al cell division and proliferation and to treat bacterial infections.
La présente invention concerne des composés de formule I : formule (I) dans laquelle les X1 à X4 et les R1 à R12 ont l'une quelconque des correspondances définies dans la spécification, ainsi que leurs sels et promédicaments, qui inhibent les principaux mécanismes moléculaires associés à la division et à la prolifération des cellules des bactéries de sorte à être utiles pour traiter et/ou prévenir des infections bactériennes. L'invention concerne également des compositions comprenant ces composés ainsi que des procédés pour utiliser ces composés pour inhiber la division et la prolifération des cellules des bactéries et pour traiter des infections bactériennes.
Kaul Malvika
Lavoie Edmond J.
Parhi Ajit
Pilch Daniel S.
Rutgers The State University Of New Jersey
Smart & Biggar
University Of Medicine And Dentistry Of New Jersey
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