Benzo-fused azepinone and piperidinone compounds useful in...

Details Benzo-fused azepinone and piperidinone compounds useful in... Benzo-fused azepinone and piperidinone compounds useful in...

C - Chemistry, Metallurgy

07

K

C07K 5/062 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2176415

Compounds having the following formula I, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: Image (I) wherein: Y1 and Y are each independently hydrogen, alkyl, aryl, halogen, or alkoxy; X is O or S(O) t; Image , Image , A is Image , or Image ; t is zero, one or two; m and n are independently zero or one; and wherein R, R5, R5a, R5b, R6, R7, R11, q and r are defined herein.

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